Contraindicated (1)pentobarbital decreases amounts of vandetanib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Avoid coadministration with potent CYP3A4 inducers; these medicines decrease exposure to vandetanib by approximately 40%.pentobarbital will decrease the extent or influence of amlodipine by impacting hepatic/
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